期刊
JOURNAL OF APPLIED POLYMER SCIENCE
卷 138, 期 13, 页码 -出版社
WILEY
DOI: 10.1002/app.50114
关键词
3D printing; bone repair biomaterials; cytotoxcity; heterogeous bone powders; polylactic acid
资金
- International Science and Technology Cooperation Project of Guangzhou Economic Technological Development Zone [2017GH09]
- Natural Science Foundation of Guangdong Province [2020A1515011004]
- Natural Science Foundation of Guangdogn Province [2020A1515010102]
- Science and Technology of Guangdong Province [2020A0505100050]
By modifying bone powder and incorporating a suitable plasticizer, this study successfully prepared PLA-based composite materials with excellent mechanical properties and biocompatibility, verifying their potential application in 3D printing personalized bone repair.
Polylactic acid (PLA) has become a popular polymer material due to its superior biocompatibility. At present, there are a few relevant research on heterogeneous bone powder. Besides, the poor dispersibility and adhesivity of inorganic particles in the organic phase remains a problem. In this study, the pork bone powders were modified with N-butanol to improve its dispersibility and compatibility in the PLA matrix. In addition, polybutylene succinate-co-terephthalates (PBSA) was applied as a flexibilizer to further reinforce the mechanical properties of materials. The composite filaments with a diameter of 1.75 +/- 0.05 mm containing 10 wt% of modified bone powder, 10 wt% PBSA and 80 wt% PLA were prepared by a melt blending method. The obtained results showed that modified particles were uniformly dispersed within the PLA matrix and improved the mechanical properties of the composite filaments with a tensile strength of 48.5 +/- 0.2 MPa and a bending strength of 79.1 +/- 0.1 MPa and a notch impact strength of 15.8 +/- 0.3 kJ/m(2). And the prepared composite materials contained low cytotoxicity, high biocompatibility and printability, which verified the feasibility of it in 3D printing personalized bone repair applications. This provides a theoretical basis for further research on the effect of bone repair in vivo. Therefore, the composite material will have potential applications such as making customized bones and bone scaffolds by three dimensional printing technology.
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