期刊
JOURNAL OF APPLIED POLYMER SCIENCE
卷 138, 期 19, 页码 -出版社
WILEY
DOI: 10.1002/app.50386
关键词
biomaterials; biomedical applications; biopolymers and renewable polymers; drug delivery systems; nanostructured polymers
资金
- Science and Engineering Research Board [EEQ/2016/000040]
- DST-Nanomission [SR/NM/NS-1005/2015]
The synthesis and utilization of plate-like-coral shaped polymer capsule (PC-PLCDB) with dendritic network structure and porous channels for therapeutic purposes has been achieved. The loading of anticancer drug doxorubicin (DOX) in PC-PLCDB showed promising results in inhibiting chronic myeloid leukemia cells (K562) growth, indicating potential applications in therapeutic treatments.
'Plate-like-coral' shaped polymer capsule (PC-PLCDB) with dendritic network structure and porous channels has been synthesized and used for therapeutic purposes. First di-block copolymer [(PEG)-b-(L-AspA)(n)] has been synthesized from PEG (polyethylene glycol) and aspartic acid (AspA). Then the biocompatible PC-PLCDB has been achieved by homogeneous mixing of [(PEG)-b-(L-AspA)(n)] and poly-N-isopropyl acrylamide (PNIPAM) followed by reprecipitation. Only H-bonding is responsible for the foundation of self-assembly of the polymer chains and to form PC-PLCDB. A huge extent of loading anticancer drug, for example, doxorubicin (DOX) in PC-PLCDB is possible. in vitro study has been performed to check the therapeutic efficacy of PC-PLCAD-DOX formulation on chronic myeloid leukemia cells (K562). The IC50 has been calculated to be 0.405 (+/- 0.014) ng mu g(-1) of the formulation. PC-PLCAD-DOX inhibits 80% of the cancer cell only by 1.0 mu g mL(-1) of the formulation. This study reveals that the PC-PLCAD could be a promising candidate for therapeutic applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据