期刊
JOURNAL OF APPLIED MICROBIOLOGY
卷 131, 期 4, 页码 1668-1682出版社
WILEY
DOI: 10.1111/jam.15012
关键词
biotechnological products; human health; indoleamines; micro‐ organisms; serotonin and melatonin biosynthesis
资金
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) [P-UE 2016-0012]
- Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT), Argentina [PICT-2018-04505]
Micro-organisms have the ability to produce biologically active compounds associated with neurotransmission. Serotonin and melatonin-producing microbes are valuable sources for eco-friendly bioproducts with positive effects on human health. Further studies on microbial synthesis of indoleamines are needed for sustainable production of foods and pharmaceuticals.
Micro-organisms have showed the ability to produce biologically active compounds associated with neurotransmission in higher organisms. In particular, serotonin- and melatonin-producing microbes are valuable sources for the development of eco-friendly bioproducts. Serotonin and melatonin are indoleamines that have received special attention due to their positive effects on human health. These biomolecules exert a critical role in several physiological or pathological processes, including some mental and neurological disorders. This article includes a review of the microbial production of serotonin and melatonin, their functions in micro-organisms and their potential uses as therapeutic and/or preventive agents to improve human health. A description of the quantification methods employed to detect indoleamines and the evidence found concerning their microbial production at laboratory and industrial scale-for application in biotechnological products-is also provided. The microbial ability to synthesize beneficial indoleamines should be further studied and harnessed, to allow the development of sustainable bioprocesses to produce foods and pharmaceuticals for human health.
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