期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 80, 期 1, 页码 331-335出版社
IOS PRESS
DOI: 10.3233/JAD-201495
关键词
Brain magnetic resonance imaging; cerebral microbleeds; dementia with Lewy bodies; Parkinson's disease; Tc-99m-ECD SPECT subtraction imaging
资金
- Japan Agency for Medical Research and Development [7211700121, 7211800049, 7211800130]
- [17H0419611]
- [17H0975609]
- [17K1082709]
- [20K12044]
Patients with dementia with Lewy bodies have a higher total number and prevalence of cerebral microbleeds compared to those with Parkinson's disease, with different common locations. Tc-99m-ECD SPECT subtraction imaging shows lower cerebral blood flow in the posterior cingulate gyrus of DLB patients.
Background: Cerebral microbleeds (CMBs) in patients with Parkinson's disease (PD) or dementia with Lewy bodies (DLB) have not been adequately studied. Objective: This study aims to find a difference in the total number, prevalence, and common locations of CMBs between PD and DLB and evaluate Tc-99m-ECD SPECT subtraction images of these two diseases. Methods: We examined 112 patients with PD (53 males and 59 females; age: 77.4 +/- 3.6 years) and 28 age-matched patients with DLB (15 males and 13 females; age: 77.1 +/- 6.7 years) using brain magnetic resonance imaging (MRI) and Tc-99m-ECD SPECT subtraction imaging. Results: The total number of CMBs was higher in patients with DLB (41.2%) than in those with PD (11.5%), and the prevalence was significantly higher in the former (0.7 +/- 1.1) than the latter (0.2 +/- 0.5, p < 0.05). The odds ratio was 5.4 (95% confidence interval [CI]: 1.7-17.4). Furthermore, CMBs were commonly located in the basal ganglia of patients with PD (6 out of 87 patients) but in the occipital lobe of patients with DLB (8 out of 17 patients). Tc-99m-ECD SPECT subtraction imaging indicated lower cerebral blood flow in the posterior cingulate gyrus among the patients with CMB-positive DLB than among those with CMB-positive PD; additionally, the cerebral blood flow was lower in the bilateral basal ganglia and midbrain among patients with CMB-positive DLB compared to those with CMB-negative DLB. Conclusion: A reduction in occipital glucose metabolism may be related to CMBs in the occipital lobe of patients with DLB.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据