期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 69, 期 4, 页码 1291-1299出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.0c06534
关键词
lycopene; di(2-ethylhexyl) phthalate; pyroptosis; Caspase-1/NLRP3 pathway; inflammatory response
资金
- Excellent Youth Foundation of Heilongjiang Province of China [JC2017005]
- National Natural Science Foundation of China [31572586]
- China Agriculture Research System [CARS-35]
The study demonstrated that lycopene could alleviate spleen injury induced by DEHP by inhibiting pyroptosis and the inflammatory response. This suggests that lycopene may be a new strategy to mitigate DEHP-induced spleen injury.
Lycopene (Lyc) as a natural antioxidant has attracted widespread attention. Di(2-ethylhexyl) phthalate (DEHP) can cause serious spleen injury in animals via the environment and food chain. For investigation of whether Lyc could alleviate DEHP-exerted pyroptosis in spleen through inhibiting the Caspase-1/NLRP3 pathway activation, 140 male mice were randomly divided into 7 groups: control group, vehicle control group, Lyc group (5 mg/kg BW/day), DEHP-exposed group (500 or 1000 mg/kg BW/day, respectively), and DEHP + Lyc groups by daily administration for 28 days. Pathological results showed that the supplementation of Lyc alleviated DEHP-induced inflammatory infiltration. Moreover, the addition of Lyc inhibited DEHP-induced Caspase-1, NLRP3, ASC, NF-kappa B, IL-1 beta, and IL-18 overexpression and GSDMD down-expression. These results indicate that Lyc could inhibit DEHP-induced Caspase-1-dependent pyroptosis and the inflammatory response. Taken together, the study provided new evidence that Lyc may be a strategy to mitigate spleen injury induced by DEHP.
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