期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 278, 期 -, 页码 57-65出版社
ELSEVIER
DOI: 10.1016/j.jad.2020.09.063
关键词
Fetal programming; Mental disorders; Prenatal stress; Depression; Anxiety
资金
- Academy of Finland
- European Union [SC1-2016-RTD-733280]
- European Commission Dynamics of Inequality Across the Life-course: structures and processes (DIAL) [724363]
- University of Helsinki Research Funds
- Signe and Ane Gyllenberg Foundation
- Diabetes Research Foundation
- Emil Aaltonen Foundation
- Finnish Medical Foundation
- Foundation for Pediatric Research
- Foundation for Cardiovascular Research
- Jane and Aatos Erkko Foundation
- Novo Nordisk Foundation
- Paivikki and Sakari Sohlberg Foundation
- Sigrid Juselius Foundation
- Sir Jules Thorn Charitable Trust
- British Heart Foundation [RE/18/5/34216]
- EVO (a special state subsidy for health science research)
Maternal antenatal stress, including symptoms of depression, anxiety, and perceived stress, is associated with a higher risk of childhood mental and behavioral disorders. Especially when mothers report consistently high levels of all types of stress throughout pregnancy.
Background: Maternal antenatal stress, including symptoms of depression, anxiety and perceived stress, is associated with mental and behavioral problems in children. Whether it is associated with child mental and behavioral disorders remains uncertain. We examined if maternal antenatal symptoms of depression, anxiety and perceived stress were associated with mental and behavioral disorders in their children, if the associations varied according to gestational week, stress type, fluctuating or consistently high symptoms, and if they were driven by maternal or paternal lifetime mood or anxiety disorders. Methods: 3365 mothers participating in the Prediction and Prevention of Preeclampsia and Intrauterine Growth Restriction (PREDO) study completed the Center for Epidemiologic Studies Depression Scale, the State Anxiety Inventory and the Perceived Stress Scale up to 14 times throughout pregnancy. The Care Register for Health Care provided data on mental and behavioral (including neurodevelopmental) disorders for their children from birth (11/07/2006-07/24/2010) until 12/31/2016 and for parental lifetime mood and anxiety disorders until 12/31/ 2016. Results: The hazard of any childhood mental and behavioral disorder (HR=1.91, 95% CI: 1.39-2.51) was significantly higher for children whose mothers reported consistently high in comparison to consistently low levels of all types of stress throughout pregnancy. The associations remained significant when adjusted for maternal and paternal lifetime mood and anxiety disorders (and their comorbidity and timing and mood disorder type). Conclusion: Maternal antenatal stress is associated with higher risk of childhood mental and behavioral disorders. Efforts to reduce maternal antenatal stress should be given a high priority to improve child mental health.
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