期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/ijms22020617
关键词
bis-azetidinone derivatives; dual antibiotics; podands; siderophores; bis beta-lactam; bis beta-lactam macrocycles
资金
- University of Salerno, Fondi di Ateneo per la Ricerca di Base [ORSA170308, ORSA180380, ORSA199808, ORSA177918, ORSA180178]
- Italian Ministry of University and Research [2017483NH8]
Beta-lactam antibiotics are a large family of compounds obtained through chemical modifications, with the potential for developing innovative antibiotics with broader spectrum of action.
beta-lactam antibiotics are among the most important and widely used antimicrobials worldwide and are comprised of a large family of compounds, obtained by chemical modifications of the common scaffolds. Usually these modifications include the addition of active groups, but less frequently, molecules were synthesized in which either two beta-lactam rings were joined to create a single bifunctional compound, or the azetidinone ring was joined to another antibiotic scaffold or another molecule with a different activity, in order to create a molecule bearing two different pharmacophoric functions. In this review, we report some examples of these derivatives, highlighting their biological properties and discussing how this strategy can lead to the development of innovative antibiotics that can represent either novel weapons against the rampant increase of antimicrobial resistance, or molecules with a broader spectrum of action.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据