4.7 Review

Relevance of Peroxisome Proliferator Activated Receptors in Multitarget Paradigm Associated with the Endocannabinoid System

期刊

出版社

MDPI
DOI: 10.3390/ijms22031001

关键词

PPAR; cannabinoids; CB1R; CB2R; FAAH; multitarget; endocannabinoid system

资金

  1. Spanish Ministry of Science and Innovation [MICIU/FEDER: RTI2018-095544-B-I00]
  2. Spanish National Research Council (CSIC) [PIE-201580E033]
  3. Comunidad de Madrid 'Atraccion de Talento' program [2018-T2/BMD-10819]

向作者/读者索取更多资源

Cannabinoids exert therapeutic effects through various targets including cannabinoid receptors and nuclear receptors. Simultaneous targeting of CBRs and PPAR alpha or PPAR gamma subtypes has shown to mediate diverse properties of cannabinoids for specific disorders.
Cannabinoids have shown to exert their therapeutic actions through a variety of targets. These include not only the canonical cannabinoid receptors CB1R and CB2R but also related orphan G protein-coupled receptors (GPCRs), ligand-gated ion channels, transient receptor potential (TRP) channels, metabolic enzymes, and nuclear receptors. In this review, we aim to summarize reported compounds exhibiting their therapeutic effects upon the modulation of CB1R and/or CB2R and the nuclear peroxisome proliferator-activated receptors (PPARs). Concomitant actions at CBRs and PPAR alpha or PPAR gamma subtypes have shown to mediate antiobesity, analgesic, antitumoral, or neuroprotective properties of a variety of phytogenic, endogenous, and synthetic cannabinoids. The relevance of this multitargeting mechanism of action has been analyzed in the context of diverse pathologies. Synergistic effects triggered by combinatorial treatment with ligands that modulate the aforementioned targets have also been considered. This literature overview provides structural and pharmacological insights for the further development of dual cannabinoids for specific disorders.

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