期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/ijms22010408
关键词
fibrosis; inflammation; RAS; PTH; FGF23; Klotho; microRNAs; vitamin D; artificial intelligence; image analysis
资金
- Instituto de Salud Carlos III (ISCIII) [PI17/00384, PI17/00715, PI19/00532, PI20/00633, PI20/00753]
- ISCIII Retic REDinREN [RD06/0016/1013, RD12/0021/0023, RD16/0009/0017, RD16/0009/0001]
- Fondo Europeo de Desarrollo Regional (FEDER), Plan Estatal de I+D+I 2013-2016, Plan de Ciencia, Tecnologia e Innovacion 2013-2017 y 2018-2022 del Principado de Asturias [GRUPIN14-028, IDI-2018-000152]
- Fundacion Renal Inigo Alvarez de Toledo (FRIAT)
- University of Oviedo [PI19/00532]
Fibrosis is a process of excessive accumulation of extracellular matrix in response to tissue injuries, which can lead to organ dysfunction. While it can play a defensive role, in certain circumstances it can become pathological and have negative impacts on kidney and heart in CKD.
Fibrosis is a process characterized by an excessive accumulation of the extracellular matrix as a response to different types of tissue injuries, which leads to organ dysfunction. The process can be initiated by multiple and different stimuli and pathogenic factors which trigger the cascade of reparation converging in molecular signals responsible of initiating and driving fibrosis. Though fibrosis can play a defensive role, in several circumstances at a certain stage, it can progressively become an uncontrolled irreversible and self-maintained process, named pathological fibrosis. Several systems, molecules and responses involved in the pathogenesis of the pathological fibrosis of chronic kidney disease (CKD) will be discussed in this review, putting special attention on inflammation, renin-angiotensin system (RAS), parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), Klotho, microRNAs (miRs), and the vitamin D hormonal system. All of them are key factors of the core and regulatory pathways which drive fibrosis, having a great negative kidney and cardiac impact in CKD.
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