期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/ijms22010068
关键词
human leukocyte antigen (HLA); MHC class I; peptide antigens; TCR binding; alpha beta TCR; alpha beta TCR; gamma delta TCR
资金
- NHMRC SRF [1159272]
- NHMRC
- National Health and Medical Research Council of Australia [1159272] Funding Source: NHMRC
T cells play a critical role in the adaptive immune system by distinguishing between healthy and unhealthy cells and aiding in clearing infections. The interaction between T cell receptors and peptide-MHC complexes is crucial for T cell activation, with recent structural biology studies providing new insights into this key event.
T cells are a critical part of the adaptive immune system that are able to distinguish between healthy and unhealthy cells. Upon recognition of protein fragments (peptides), activated T cells will contribute to the immune response and help clear infection. The major histocompatibility complex (MHC) molecules, or human leukocyte antigens (HLA) in humans, bind these peptides to present them to T cells that recognise them with their surface T cell receptors (TCR). This recognition event is the first step that leads to T cell activation, and in turn can dictate disease outcomes. The visualisation of TCR interaction with pMHC using structural biology has been crucial in understanding this key event, unravelling the parameters that drive this interaction and their impact on the immune response. The last five years has been the most productive within the field, wherein half of current unique TCR-pMHC-I structures to date were determined within this time. Here, we review the new insights learned from these recent TCR-pMHC-I structures and their impact on T cell activation.
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