4.7 Review

The Signaling Pathways Involved in the Anticonvulsive Effects of the Adenosine A1 Receptor

期刊

出版社

MDPI
DOI: 10.3390/ijms22010320

关键词

adenosine; adenosine A(1) receptor; epilepsy; signaling pathways; neuromodulation; inhibition

资金

  1. Fonds voorWetenschappelijk Onderzoek (FWO) [G042219N]

向作者/读者索取更多资源

Activation of adenosine A(1) receptor can inhibit seizures through various signaling pathways leading to neuronal inhibition. However, chronic activation of the A(1) receptor may have detrimental effects that should be avoided in the development of epilepsy therapies based on this receptor.
Adenosine acts as an endogenous anticonvulsant and seizure terminator in the brain. Many of its anticonvulsive effects are mediated through the activation of the adenosine A(1) receptor, a G protein-coupled receptor with a wide array of targets. Activating A(1) receptors is an effective approach to suppress seizures. This review gives an overview of the neuronal targets of the adenosine A(1) receptor focusing in particular on signaling pathways resulting in neuronal inhibition. These include direct interactions of G protein subunits, the adenyl cyclase pathway and the phospholipase C pathway, which all mediate neuronal hyperpolarization and suppression of synaptic transmission. Additionally, the contribution of the guanyl cyclase and mitogen-activated protein kinase cascades to the seizure-suppressing effects of A(1) receptor activation are discussed. This review ends with the cautionary note that chronic activation of the A(1) receptor might have detrimental effects, which will need to be avoided when pursuing A(1) receptor-based epilepsy therapies.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据