The Interplay between Angiopoietin-Like Proteins and Adipose Tissue: Another Piece of the Relationship between Adiposopathy and Cardiometabolic Diseases?

Angiopoietin-like proteins, namely ANGPTL3-4-8, are known as regulators of lipid metabolism. However, recent evidence points towards their involvement in the regulation of adipose tissue function. Alteration of adipose tissue functions (also called adiposopathy) is considered the main inducer of metabolic syndrome (MS) and its related complications. In this review, we intended to analyze available evidence derived from experimental and human investigations highlighting the contribution of ANGPTLs in the regulation of adipocyte metabolism, as well as their potential role in common cardiometabolic alterations associated with adiposopathy. We finally propose a model of ANGPTLs-based adipose tissue dysfunction, possibly linking abnormalities in the angiopoietins to the induction of adiposopathy and its related disorders.

Automated summary

Angiopoietin-like proteins are known regulators of lipid metabolism, but recent evidence suggests they also play a role in regulating adipose tissue function. Dysfunction in adipose tissue, known as adiposopathy, is considered a main contributor to metabolic syndrome and its related complications. Understanding the role of ANGPTLs in adipocyte metabolism could provide insights into common cardiometabolic alterations associated with adiposopathy.