期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/ijms22031009
关键词
selenium compounds; cancer; anticancer agents; molecular target; drug resistance; combinatorial therapy; chemoprevention
资金
- Medical University of Bialystok [SUB/2/DN/20/001/2217, SUB/2/DN/20/002/2217]
This review discusses the research on the anticancer activity of selenium compounds, including the different classes of selenium compounds and their mechanisms of action, which are important for developing more effective cancer treatments.
The high number of new cancer incidences and the associated mortality continue to be alarming, leading to the search for new therapies that would be more effective and less burdensome for patients. As there is evidence that Se compounds can have chemopreventive activity, studies have begun to establish whether these compounds can also affect already existing cancers. This review aims to discuss the different classes of Se-containing compounds, both organic and inorganic, natural and synthetic, and the mechanisms and molecular targets of their anticancer activity. The chemical classes discussed in this paper include inorganic (selenite, selenate) and organic compounds, such as diselenides, selenides, selenoesters, methylseleninic acid, 1,2-benzisoselenazole-3[2H]-one and selenophene-based derivatives, as well as selenoamino acids and Selol.
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