期刊
DIABETES RESEARCH AND CLINICAL PRACTICE
卷 122, 期 -, 页码 17-27出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2016.09.022
关键词
Oxytocin; Metabolic syndrome; Abdominal obesity; Men
资金
- INSERM/Merck Sharp & Dohme Chibret, France
- ''Programme Hospitalier de Recherche Clinique InterRegional - Interregion Sudme diterrannee'' - of the French Ministry of Health
Aim: Oxytocin regulates food intake, carbohydrate and lipid metabolism, and urinary sodium excretion. We assessed the association between serum oxytocin levels and presence of metabolic syndrome (MetS) in older men. Methods: Cross-sectional study was performed in 540 volunteer men aged 50-85 yrs from the MINOS cohort. Oxytocin was measured in fasting serum by radioimmunoassay (Oxytocin RIA, Phoenix Pharmaceuticals). MetS was diagnosed using the harmonized definition. Results: Serum oxytocin was higher in 166 men with MetS vs. controls (p < 0.005). After adjustment for confounders including leptin, higher oxytocin was associated with higher odds of MetS (OR = 1.38 per SD, 95% CI: 1.10-1.71, p < 0.005). Men with serum oxytocin > 0.74 pg/mL (median) had higher odds of MetS vs. men with oxytocin 60.74 pg/mL (OR = 2.06, 95% CI: 1.33-3.18, p < 0.005). Higher oxytocin levels and low testosterone levels (total or free) were significantly associated with higher odds of MetS jointly and independently of each other. Men having oxytocin > 0.74 pg/mL and total testosterone < 300 ng/dL (< 10.4 nmol/L) had higher odds of MetS vs. men without these characteristics (OR = 3.95, 95% CI: 1.65-9.46, p < 0.005). Men having 25-hydroxycholecalciferol levels < 30 ng/mL and oxytocin > 0.74 pg/mL had higher odds of MetS vs. men without these characteristics (OR = 2.86, 95% CI: 1.47-5.58, p < 0.01). Men having oxytocin > 0.74 pg/mL and osteocalcin levels < 14.6 ng/mL (lowest quartile) had higher odds of MetS vs. men without these characteristics (OR = 4.12, 95% CI: 2.07-8.20, p < 0.001). Conclusion: In older men, higher serum oxytocin levels are associated with higher odds of MetS regardless of potential confounders. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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