期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/ijms22031207
关键词
Rac1; RhoA; peripheral actin; adenosine; ATP; ADP; UTP; endothelial permeability; oedema; P2X receptors; P2Y receptors
资金
- University of Giessen Anschubfinanzierung
- UKGM [62589122]
This review discusses the influence of activation of various purinergic receptors and downstream signaling pathways on vascular permeability during pathological conditions, noting that the effects may depend on the type and prevalence of activated receptors.
Increased vascular permeability is a hallmark of several cardiovascular anomalies, including ischaemia/reperfusion injury and inflammation. During both ischaemia/reperfusion and inflammation, massive amounts of various nucleotides, particularly adenosine 5 '-triphosphate (ATP) and adenosine, are released that can induce a plethora of signalling pathways via activation of several purinergic receptors and may affect endothelial barrier properties. The nature of the effects on endothelial barrier function may depend on the prevalence and type of purinergic receptors activated in a particular tissue. In this review, we discuss the influence of the activation of various purinergic receptors and downstream signalling pathways on vascular permeability during pathological conditions.
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