期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/ijms22020902
关键词
GLP-1; taste; tongue; obesity; sweet
GLP-1 is involved in taste perception, particularly in sweet taste, through its interaction with GLP-1 receptors in taste bud cells and nerves. While the impact of GLP-1-based therapies on gustatory coding in humans remains largely unaddressed, further exploration of the tongue as a new treatment target for GLP-1 receptor agonists in clinical studies is encouraged. Pharmacological manipulation of gustatory coding may present a new potential strategy against obesity and diabetes, highlighting the topic's clinical relevance.
Preclinical studies provided some important insights into the action of glucagon-like peptide 1 (GLP-1) in taste perception. This review examines the literature to uncover some molecular mechanisms and connections between GLP-1 and the gustatory coding. Local GLP-1 production in the taste bud cells, the expression of GLP-1 receptor on the adjacent nerves, a functional continuum in the perception of sweet chemicals from the gut to the tongue and an identification of GLP-1 induced signaling pathways in peripheral and central gustatory coding all strongly suggest that GLP-1 is involved in the taste perception, especially sweet. However, the impact of GLP-1 based therapies on gustatory coding in humans remains largely unaddressed. Based on the molecular background we encourage further exploration of the tongue as a new treatment target for GLP-1 receptor agonists in clinical studies. Given that pharmacological manipulation of gustatory coding may represent a new potential strategy against obesity and diabetes, the topic is of utmost clinical relevance.
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