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Erika N. Cline et al.
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Diptaman Chatterjee et al.
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Emerging Immunotherapies for Parkinson Disease
Samis M. A. Zella et al.
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Kasandra Belanger et al.
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Justin P. Lomont et al.
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Franziska Kundel et al.
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Kin Yen Chia et al.
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Minee L. Choi et al.
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AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy
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Adriano Sebollela et al.
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Norelle C. Wildburger et al.
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New Therapeutic Strategies for Lewy Body Dementias
Latha Velayudhan et al.
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Recombinant Antibody Fragments for Neurodegenerative Diseases
Karen Manoutcharian et al.
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Oligomeric alpha-synuclein and beta-amyloid variants as potential biomarkers for Parkinson's and Alzheimer's diseases
Stephanie M. Williams et al.
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Elvira Valera et al.
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Farah El-Turk et al.
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Jeff Sevigny et al.
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Adriano Aguzzit et al.
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Lester Carter et al.
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Erwin De Genst et al.
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The protective effects and underlying mechanism of an anti-oligomeric Aβ42 single-chain variable fragment antibody
Yuan Zhang et al.
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NGL Viewer: a web application for molecular visualization
Alexander S. Rose et al.
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Polyglutamine Aggregation in Huntington Disease: Does Structure Determine Toxicity?
Guylaine Hoffner et al.
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Yuan Zhang et al.
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Erwin De Genst et al.
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Antibody-Derived In Vivo Imaging of Tau Pathology
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ESCRT-mediated Uptake and Degradation of Brain-targeted α-synuclein Single Chain Antibody Attenuates Neuronal Degeneration In Vivo
Brian Spencer et al.
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William F. Goure et al.
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Molecular Structure of β-Amyloid Fibrils in Alzheimer's Disease Brain Tissue
Jun-Xia Lu et al.
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Tim Guilliams et al.
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Muscle-Directed Anti-Aβ Single-Chain Antibody Delivery via AAV1 Reduces Cerebral Aβ Load in an Alzheimer's Disease Mouse Model
Junling Yang et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2013)
The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein
Tiziana Sonati et al.
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Philippe P. Monnier et al.
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Pauline T. Velasco et al.
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The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
Iryna Benilova et al.
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Nanobody specific for oligomeric beta-amyloid stabilizes nontoxic form
Srinath Kasturirangan et al.
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Prion protein at the crossroads of physiology and disease
Emiliano Biasini et al.
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Conformation-dependent scFv antibodies specifically recognize the oligomers assembled from various amyloids and show colocalization of amyloid fibrils with oligomers in patients with amyloidoses
Xi Zhang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2011)
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Koji Fujita et al.
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Huntington's disease: from molecular pathogenesis to clinical treatment
Christopher A. Ross et al.
LANCET NEUROLOGY (2011)
Ion mobility-mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation
Christian Bleiholder et al.
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Bifunctional Anti-Huntingtin Proteasome-Directed Intrabodies Mediate Efficient Degradation of Mutant Huntingtin Exon 1 Protein Fragments
David C. Butler et al.
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The intricate mechanisms of neurodegeneration in prion diseases
Claudio Soto et al.
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The synaptic pathology of α-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia
Walter J. Schulz-Schaeffer
ACTA NEUROPATHOLOGICA (2010)
Selection of Peptide Inhibitors of Soluble Aβ1-42 Oligomer Formation by Phage Display
Takayasu Kawasaki et al.
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Structure and Properties of a Complex of α-Synuclein and a Single-Domain Camelid Antibody
Erwin J. De Genst et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Early or Late-Stage Anti-N-Terminal Huntingtin Intrabody Gene Therapy Reduces Pathological Features in B6.HDR6/1 Mice
Abigail Snyder-Keller et al.
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Antibody fragments Hope and hype
Aaron L. Nelson
MABS (2010)
A novel anti-prion protein monoclonal antibody and its single-chain fragment variable derivative with ability to inhibit abnormal prion protein accumulation in cultured cells
Yoshihisa Shimizu et al.
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Vincenza Campana et al.
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H-1, C-13 and N-15 assignments of a camelid nanobody directed against human alpha-synuclein
Anneleen Vuchelen et al.
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Sharareh Emadi et al.
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Amber L. Southwell et al.
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Aaron L. Nelson et al.
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Erik Kvam et al.
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Sara Imarisio et al.
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Anti-oligomeric single chain variable domain antibody differentially affects huntingtin and α-synuclein aggregates
Brent L. Nannenga et al.
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Chuan-En Wang et al.
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Sandra M. Lynch et al.
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Anti-oligomeric Aβ Single-chain Variable Domain Antibody Blocks Aβ-induced Toxicity Against Human Neuroblastoma Cells
Andleeb Zameer et al.
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Amber L. Southwell et al.
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Epitope mapping and neuroprotective properties of a human single chain FV antibody that binds an internal epitope of amyloid-beta 1-42
R. S. Solorzano-Vargas et al.
MOLECULAR IMMUNOLOGY (2008)
Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer's disease
Melanie Meyer-Luehmann et al.
NATURE (2008)
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
Ganesh M. Shankar et al.
NATURE MEDICINE (2008)
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Utpal Das et al.
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Properties, production, and applications of camelid single-domain antibody fragments
M. M. Harmsen et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2007)
Soluble oligomers from a non-disease related protein mimic Aβ-induced tau hyperphosphorylation and neurodegeneration
Marcelo N. N. Vieira et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Isolation of a human single chain antibody fragment against oligomeric α-synuclein that inhibits aggregation and prevents α-synuclein-induced toxicity
Sharareh Emadi et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Soluble protein oligomers in neurodegeneration:: lessons from the Alzheimer's amyloid β-peptide
Christian Haass et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Monoclonal antibodies that target pathological assemblies of A beta
Mary P. Lambert et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Formation of soluble oligomers and amyloid fibrils with physical properties of the scrapie isoform of the prion protein from the C-terminal domain of recombinant murine prion protein mPrP-(121-231)
Samantha M. Martins et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Inhibition of prion propagation in scrapie-infected mouse neuroblastoma cell lines using mouse monoclonal antibodies against prion protein
K Miyamoto et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Paracrine inhibition of prion propagation by anti-PrP single-chain Fv miniantibodies
G Donofrio et al.
JOURNAL OF VIROLOGY (2005)
Clinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial
S Gilman et al.
NEUROLOGY (2005)
Engineered antibody fragments and the rise of single domains
P Holliger et al.
NATURE BIOTECHNOLOGY (2005)
A beta 42 immunization in Alzheimer's disease generates A beta N-terminal antibodies
M Lee et al.
ANNALS OF NEUROLOGY (2005)
A single-chain Fv intrabody provides functional protection against the effects of mutant protein in an organotypic slice culture model of Huntington's disease
RC Murphy et al.
MOLECULAR BRAIN RESEARCH (2004)
A human single-chain Fv intrabody blocks aberrant cellular effects of overexpressed α-synuclein
C Zhou et al.
MOLECULAR THERAPY (2004)
Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease
I Ferrer et al.
BRAIN PATHOLOGY (2004)
Alzheimer's disease-affected brain:: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss
YS Gong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
R Kayed et al.
SCIENCE (2003)
Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide:: a case report
JAR Nicoll et al.
NATURE MEDICINE (2003)
Biophysical properties of human antibody variable domains
S Ewert et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
M Bucciantini et al.
NATURE (2002)
Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity
A Khoshnan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Antibodies inhibit prion propagation and clear cell cultures of prion infectivity
D Peretz et al.
NATURE (2001)
Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease
JM Lecerf et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
The structural basis of protein folding and its links with human disease
CM Dobson
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2001)
Stability engineering of antibody single-chain Fv fragments
A Wörn et al.
JOURNAL OF MOLECULAR BIOLOGY (2001)
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders
L Buée et al.
BRAIN RESEARCH REVIEWS (2000)
Fibrils formed in vitro from α-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid
KA Conway et al.
BIOCHEMISTRY (2000)
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