期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 168, 期 -, 页码 620-630出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.11.115
关键词
Fucoidan; Skin barrier; Fine-dust
资金
- Korea Institute of Marine Science & Technology Promotion (KIMST) [M01201920180359]
The study found that fucoidan derived from brown algae can alleviate the effects of fine-dust on skin inflammation and restore skin barrier function. SHC4-6 exerts this effect by reducing ROS levels and inhibiting inflammatory cytokines.
Recently evidence linking the effects of fine-dust (FD) on skin inflammation is exaggerating. Fucoidan derived from brown algae has great potential for ameliorating oxidative stress and inflammation. Herein, a fucoidan fraction (SHC4-6) was purified from an enzymatic (Celluclast) extract of an invasive seaweed, Sargassumhorneri following gradient ethanol precipitation and anion exchange chromatography. Effectiveness of SHC4-6 in ameliorating FD (from Beijing, China)-induced inflammatory responses in HaCaT keratinocytes and recovery of skin barrier dysfunction was evaluated. SHC4-6 was comprising of sulfated mannofucans with their molecular weights distributed around 45 kDa. SHC4-6 dose- dependently lowered ROS levels in FD-induced HaCaT keratinocytes, ameliorating viability at 50 mu g mL(-1). SHC4-6 downregulated inflammatory cytokines, tumor necrosis factor-alpha, interleukin (IL)-1 beta, -5, -6, -8, -13, interferon-gamma, and chemokines, macrophage-derived chemokine, eotaxin, and thymus and activation regulated chemokine by inhibiting mitogen-activated protein kinase and nuclear factor-kappa B pathways. SHC4-6 treatment ameliorated key tight junction proteins and skin hydration factors, depicting the effects of fucoidan in reducing FD-induced inflammation and skin barrier deterioration. With further studies in place, SHC4-6 could be used as an ingredient for developing cosmetics to relieve FD-induced skin inflammation. (C) 2020 Elsevier B.V. All rights reserved.
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