期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 167, 期 -, 页码 687-718出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.11.151
关键词
Cellulose; Silk fibroin; Ionic liquids; Fibers; Composites; Tissue engineering
资金
- FAPESP [2014/22136-4, 2016/22869-7, 2017/06394-1]
- Swedish Research Council Formas [942-2015-388]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [16/22869-7, 17/06394-1] Funding Source: FAPESP
This review explores composites prepared from cellulose and silk fibroin for tissue engineering applications. The discussion on molecular structures, dissolution mechanisms, and fabrication and characterization of these materials reveals that they exhibit improved mechanical properties compared to precursor biopolymers, making them excellent candidates for biomedical applications due to their inherent biocompatibility.
This review addresses composites prepared from cellulose (Cel) and silk fibroin (SF) to generate multifunctional, biocompatible, biodegradable materials such as fibers, films and scaffolds for tissue engineering. First, we discuss briefly the molecular structures of Cel and SF. Their structural features explain why certain solvents, e.g., ionic liquids, inorganic electrolyte solutions dissolve both biopolymers. We discuss the mechanisms of Cel dissolution because in many cases they also apply to (much less studied) SF dissolution. Subsequently, we discuss the fabrication and characterization of Cel/SF composite biomaterials. We show how the composition of these materials beneficially affects their mechanical properties, compared to those of the precursor biopolymers. We also show that Cel/SF materials are excellent and versatile candidates for biomedical applications because of the inherent biocompatibility of their components. (C) 2020 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据