期刊
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
卷 57, 期 1, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijantimicag.2020.106227
关键词
Enterococcus faecium; High-risk clones; Hospital-associated clones; Clade A1; Genetic capitalism; WGS strain typing
资金
- Applied Molecular Biosciences Unit - UCIBIO - national funds from FCT [UIDB/04378/2020]
- QREN [NORTE-01-0145-FEDER-000024, NORTE-010145-FEDER-000011]
- FCT/MCTES [CEECIND/02268/2017, SFRH/BD/144401/2019]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/144401/2019] Funding Source: FCT
Enterococcus faecium is a significant opportunistic human pathogen that has evolved towards a powerful adaptation to healthcare environments. However, the relevance of its dispersal in non-human hosts is still unknown.
Enterococcus faecium is a significant opportunistic human pathogen with a broad host range, including humans, farm animals, pets and wildlife. Specialised subpopulations have globally evolved towards a powerful and convergent adaption to the healthcare environment by acquiring a cocktail of key antimicrobial resistance and virulence genes, enabling them to thrive in the disturbed microbiota of hospitalised patients. These populations can also be found in different community reservoirs, but the relevance of their dispersal in non-human hosts is greatly unknown and is here discussed. This review provides a brief historical overview of what we have been considering E. faecium high-risk clones worldwide alongside the advances in strain typing technologies that have revolutionised our understanding of the genetic evolution of this species over the last three decades. (C) 2020 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved.
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