Tumor cell invasiveness in the initial stages of bladder cancer development - A computational study

Bladder cancer is one of the most common types of cancer, being the sixth more frequent in men, and one with higher recurrence rates and overall treatment costs. We introduce an agent-based computational model of the urothelium, adopting a Cellular Potts Model (CPM) approach to describe both a healthy urothelium and the development of bladder cancer. We focus on the identification of the conditions in which cancer cells cross, by mechanical means, the basement membrane and invade the bladder lamina propria. When within the urothelium the tumor grows in a very constrained environment. These tight conditions imply that the urothelium layer where the tumor initiates greatly determines tumor growth and invasiveness. Moreover, we demonstrate how specific mechanical properties of the cancer cells, as their stiffness or the adhesion to neighboring cells, heavily modulate the critical initial moments of tumor development. We propose that these characteristics should be considered as therapeutic targets to control tumor growth.

Automated summary

Bladder cancer is a common type of cancer with high recurrence rates and treatment costs, and a computational model was introduced to study the development of bladder cancer and how specific mechanical properties of cancer cells can modulate tumor growth and invasiveness. Mechanical means of cancer cell invasion through the urothelium, and the constraints of the urothelium layer greatly influence tumor development and can be considered as therapeutic targets to control tumor growth.