期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 90, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.intimp.2020.107117
关键词
Bixin; Renal inflammation; Fibrosis; Oxidative stress; Nrf2; PPAR-gamma
资金
- National Natural Science Foundation of China [31972942]
- Returned Students and Doctor Scientific Research for the Second Time by Sichuan University of Science and Engineering [2017RCL66]
- Graduate Student Scientific Research Innovation Projects of Jiangsu Education Department [SJKY19-2064]
Bixin extracted from Bixa orellana seeds possesses anti-inflammatory, antioxidant, and anti-fibrosis properties by regulating the Nrf2/TLR4/MyD88 and PPAR-gamma/TGF-beta 1/Smad3 pathways, improving renal damage induced by carbon tetrachloride in mice.
Bixin, an natural carotenoid extracted from the seeds of the Bixa orellana has been shown to possess numerous important pharmacological activities. The present study was aimed to investigate the mechanisms of Bixin on carbon tetrachloride (CCl4)-induced kidney inflammation, fibrosis and oxidative stress in mice. Our results showed that Bixin improved renal damage by decreasing the serum levels of creatinine, urea, uric acid and alleviating kidney fibrosis. Bixin ameliorated CCl4-induced inflammation in kidneys by reducing the levels of TNF-alpha and IL-1 beta. Bixin suppressed oxidative stress by decreasing the MDA level and increasing the activation of SOD, CAT and GPx. Furthermore, Bixin increased the levels of PPAR-gamma, NQO1, HO-1 and the nuclear translocation of Nrf2 in the kidneys of mice. Bixin supplementation inhibited the activation of TLR4, MyD88, NF-kappa B, TGF-beta and Smad3. Thus, this study demonstrated that Bixin possesses anti-oxidant, anti-inflammatory and antifibrosis properties through regulating the Nrf2/TLR4/MyD88 and PPAR-gamma/TGF-beta 1/Smad3 pathways.
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