期刊
INSECT MOLECULAR BIOLOGY
卷 30, 期 3, 页码 277-286出版社
WILEY
DOI: 10.1111/imb.12694
关键词
Apis mellifera; epigenetic; honey bee; Juvenile hormone; Vitellogenin receptor (VgR); Kruppel-homologue 1 (Kr-h1); DNA methyltransferase 3 (Dnmt3) and the Forkhead box O transcription factor (FoxO)
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [2016/15881-0, 2017/09269-3]
- Australian Research Council [DP180101696]
Social insects, like honeybees, have two female castes with extreme differences in reproductive capacity. The study found that the expression of Vitellogenin (Vg) in the ovaries of worker bees is influenced by Royal Jelly, the food of honeybee queens. Surprisingly, the expression of Vg is not linked to ovary activation in worker bees, suggesting potential non-reproductive functions for this gene.
Social insects are notable for having two female castes that exhibit extreme differences in their reproductive capacity. The molecular basis of these differences is largely unknown. Vitellogenin (Vg) is a powerful antioxidant and insulin-signalling regulator used in oocyte development. Here we investigate how Royal Jelly (the major food of honeybee queens) and queen mandibular pheromone (a major regulator of worker fertility), affect the longevity and reproductive status of honey bee workers, the expression of Vg, its receptor VgR and associated regulatory proteins. We find that Vg is expressed in the ovaries of workers and that workers fed a queen diet of Royal Jelly have increased Vg expression in the ovaries. Surprisingly, we find that expression of Vg is not associated with ovary activation in workers, suggesting that this gene has potentially acquired non-reproductive functions. Therefore, Vg expression in the ovaries of honeybee workers provides further support for the Ovarian Ground Plan Hypothesis, which argues that genes implicated in the regulation of reproduction have been co-opted to regulate behavioural differences between queens and workers.
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