期刊
IMMUNOLOGY
卷 162, 期 3, 页码 328-338出版社
WILEY
DOI: 10.1111/imm.13288
关键词
CD1d; hepatocyte; schistosomiasis; immunopathology
类别
资金
- National Key Research and Development Program of China (MOST) [2018YFA0507300]
- National Natural Science Foundation of China (NSFC) [81971963, 81871675]
- Natural Science Foundation of Jiangsu Province [BK20170105]
Schistosomiasis is a neglected tropical disease affecting over 250 million people worldwide, caused primarily by Schistosoma mansoni and Schistosoma japonicum. CD1d plays a crucial role in maintaining liver NKT cell homeostasis and modulating immune responses. Decreased CD1d expression on hepatocytes during S. japonicum infection leads to increased NKT cells, altered Th1 and Th2 responses, and liver immunopathology, while overexpression of CD1d in hepatocytes can alleviate these effects.
Schistosomiasis is a neglected tropical disease with over 250 million people infected worldwide. The main clinically important species Schistosoma mansoni (S. mansoni) and Schistosoma japonicum (S. japonicum) cause inflammatory responses against tissue-trapped eggs, resulting in formation of granulomas mainly in host liver. Persistent granulomatous response results in severe fibrosis in the liver, leading to irreversible impairment of the liver and even death of the host. CD1d, a highly conserved MHC class I-like molecule, is expressed by both haematopoietic and non-haematopoietic cells. CD1d on antigen-presenting cells (APCs) of haematopoietic origin presents pathogen-derived lipid antigens to natural killer T (NKT) cells, which enables them to rapidly produce large amounts of various cytokines and facilitate CD4(+) T helper (Th) cell differentiation upon invading pathogens. Noteworthy, hepatocytes of non-haematopoietic origin have recently been shown to be involved in maintaining liver NKT cell homeostasis through a CD1d-dependent manner. However, whether hepatocyte CD1d-dependent regulation of NKT cell homeostasis also modulates CD4(+) Th cell responses and liver immunopathology in murine schistosomiasis remains to be addressed. Here, we show in mice that CD1d expression on hepatocytes was decreased dramatically upon S. japonicum infection, accompanied by increased NKT cells, as well as upregulated Th1 and Th2 responses. Overexpression of CD1d in hepatocytes significantly decreased local NKT numbers and cytokines (IFN-gamma, IL-4, IL-13), concomitantly with downregulation of both Th1 and Th2 responses and alleviation in pathological damage in livers of S. japonicum-infected mice. These findings highlight the potential of hepatocyte CD1d-targeted therapies for liver immunopathology control in schistosomiasis.
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