期刊
IMMUNOGENETICS
卷 73, 期 1, 页码 65-77出版社
SPRINGER
DOI: 10.1007/s00251-020-01195-1
关键词
IgT; IgD; pIgR; V(D)J recombination; IgM concentration
Immunoglobulins, including IgM, IgT, and IgD, in teleosts are produced through VDJ recombination and somatic hypermutation, providing diversity in immune response. IgM serves as the main effector molecule in both systemic and mucosal immunity, while IgT is considered the main mucosal Ig.
Immunoglobulins are glycoproteins which are produced as membrane-bound receptors on B-cells or in a secreted form, known as antibodies. In teleosts, three immunoglobulin isotypes, IgM, IgT, and IgD, are present, each comprising two identical heavy and two identical light polypeptide chains. The basic mechanisms for generation of immunoglobulin diversity are similar in teleosts and higher vertebrates. The B-cell pre-immune repertoire is diversified by VDJ recombination, junctional flexibility, addition of nucleotides, and combinatorial association of light and heavy chains, while the post-immune repertoire undergoes somatic hypermutation during clonal expansion. Typically, the teleost immunoglobulin heavy chain gene complex has a modified translocon arrangement where the D tau-J tau-C tau cluster of IgT is generally located between the variable heavy chain (VH) region and the D mu/delta-J mu/delta-C mu-C delta gene segments, or within the set of VH gene segments. However, multiple genome duplication and deletion events and loss of some individual genes through evolution has complicated the IgH gene organization. The IgH gene arrangement allows the expression of either IgT or IgM/IgD. Alternative splicing is responsible for the regulation of IgM/IgD expression and the secreted versus transmembrane forms of IgT, IgD, and IgM. The overall structure of IgM and IgT is usually conserved across species, whereas IgD has a large variety of structures. IgM is the main effector molecule in both systemic and mucosal immunity and shows a broad range of concentrations in different teleost species. Although IgM is usually present in higher concentrations under normal conditions, IgT is considered the main mucosal Ig.
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