期刊
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
卷 68, 期 1, 页码 54-64出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TUFFC.2020.3006781
关键词
Transducers; Ultrasonic imaging; Acoustics; Frequency control; Magnetic resonance imaging; Power supplies; Optical transmitters; Low intensity focused ultrasound pulsation (LIFUP); low intensity focused ultrasound (LIFU); neuromodulation; transducer; ultrasound
资金
- Brainsonix Corporation
- Pacific Institute of Medical Research
- Tiny Blue Dot Foundation
The study introduces a novel noninvasive low-intensity focused ultrasound pulsation neuromodulation method, which includes system design, control software, calibration, and alignment techniques, aiming to simplify the work for researchers and providing examples of neurostimulation targeting.
Noninvasive low-intensity focused ultrasound pulsation (LIFUP) neuromodulation provides a unique approach to both investigating and treating the brain. This work describes a well-calibrated, simple-to-use ultrasound stimulation system for neuromodulation studies. It provides a single-element 650-kHz transducer design and a straightforward control mechanism, with extensive calibration and internal electronic monitoring to prevent unwanted over or under treatment. One goal of this approach is to relieve researchers of many of the details associated with developing their own exposure equipment. A unique transducer positioning system and distinctive MRI fiducial targets simplify alignment and targeting. The system design, control software, calibration, and alignment techniques are described in detail. Examples of transducer targeting and neurostimulation using the system are provided.
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