期刊
HYPERTENSION
卷 77, 期 3, 页码 1001-1009出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/HYPERTENSIONAHA.120.16238
关键词
blood; heart rate; nitric oxide; syndrome; tachycardia
资金
- National Institutes of Health (NIH) [UL1 TR000445]
The study found that patients with PoTS have significantly reduced flow-mediated dilation compared with healthy controls, suggesting that PoTS is characterized by endothelial dysfunction in conduit arteries.
The purpose of this study is to evaluate endothelial function in postural tachycardia syndrome (PoTS), a poorly understood chronic condition characterized by a state of consistent orthostatic tachycardia (delta heart rate >= 30 beats per minute) upon standing without orthostatic hypotension. Nineteen patients with PoTS and 9 healthy controls were studied after 3 days of a fixed, caffeine-free, normal sodium (150 milliequivalents/day) diet. All participants underwent autonomic function testing, including sinus arrhythmia, valsalva maneuver, hyperventilation, cold pressor, handgrip, and a standing test with catecholamine measurements, followed by endothelial function testing. We analyzed 3 measures of endothelial function: percent brachial flow-mediated dilation, digital pulsatile arterial tonometry, and postischemic percent leg blood flow. Flow-mediated dilation was significantly lower in patients with PoTS (6.23 +/- 3.54% for PoTS) than in healthy controls (10.6 +/- 4.37% for controls versus, P=0.014). PoTS and controls had similar digital pulsatile arterial tonometry (1.93 +/- 0.40 arbitrary units for controls versus 2.13 +/- 0.63 arbitrary units for PoTS). PoTS had similar but suggestive percent leg blood flow to controls (313 +/- 158% for PoTS versus 468 +/- 236% for controls, P=0.098). Patients with PoTS have significantly reduced flow-mediated dilation compared with healthy controls, suggesting that PoTS is characterized by endothelial dysfunction in conduit arteries.
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