期刊
HYPERTENSION
卷 77, 期 1, 页码 28-38出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/HYPERTENSIONAHA.120.16064
关键词
exosomes; extracellular vesicles; hypertension; kidney diseases; therapeutics
资金
- Carlos III Health Institute [PI16/01402, PI18/01405, PI19/01796]
- ERDF (European Regional Development Fund) funds
Extracellular vesicles play a key role in hypertension and hypertension-related renal damage, serving as potential therapeutic agents and markers for kidney damage. The ability of exosomes to efficiently deliver various cargos to target cells makes them a promising drug delivery system for the treatment of renal diseases.
Hypertension-mediated organ damage frequently includes renal function decline in which several mechanisms are involved. The present review outlines the state of the art on extracellular vesicles in hypertension and hypertension-related renal damage. Emerging evidence indicates that extracellular vesicles, small vesicles secreted by most cell types and body fluids, are involved in cell-to-cell communication and are key players mediating biological processes such as inflammation, endothelial dysfunction or fibrosis, mechanisms present the onset and progression of hypertension-associated kidney disease. We address the potential use of extracellular vesicles as markers of hypertension-mediated kidney damage severity and their application as therapeutic agents in hypertension-associated renal damage. The capacity of exosomes to deliver a wide variety of cargos to the target cell efficiently makes them a potential drug delivery system for treatment of renal diseases.
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