期刊
HORMONE AND METABOLIC RESEARCH
卷 53, 期 2, 页码 75-84出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1298-4205
关键词
SGLT2 inhibitor; sympathetic nervous system; type 2 diabetes
资金
- Bulgarian Ministry of Education and Science under the National Program for Research Young Scientists and Postdoctoral Students
SGLT2 inhibitors increase renal glucose excretion, decrease blood glucose levels, and may play a role in cardiovascular protection for patients with type 2 diabetes by inhibiting sympathetic nerve tone.
SGLT2 inhibitors increase renal glucose excretion and thus decrease both fasting and postprandial plasma glucose levels. The effects of SGLT2 inhibition outweigh those on glycemic control and are also associated with the induction of hemodynamic changes that improve cardiovascular and renal function in people with type 2 diabetes. The exact mechanisms have not yet been completely clarified. This review is focused on the potential relationship between SGLT2 inhibition and sympathetic nerve activity. There is accumulating evidence for a suppressive effect of SGLT2 inhibitors on the sympathetic nerve tone, which might be a putative mechanism for cardiovascular protection in subjects with type 2 diabetes.
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