期刊
HEPATOLOGY RESEARCH
卷 51, 期 4, 页码 436-444出版社
WILEY
DOI: 10.1111/hepr.13617
关键词
chronic liver disease; liver fibrosis and necroinflammation; liver stiffness; TE; VTQ
资金
- Hyogo College of Medicine
- JSPS KAKENHI [JP 18K07985]
The study aimed to investigate the correlation between liver stiffness measured by SWE and hepatic necroinflammation, revealing that liver stiffness values significantly increased with the progression of liver fibrosis and inflammation, but were not affected by hepatic necroinflammation in F4 fibrosis.
Aim Shear wave elastography (SWE) in patients with chronic liver diseases is a noninvasive useful method for the diagnosis of liver fibrosis severity, which can be an alternative to liver biopsy. However, the liver stiffness measurement using SWE can be affected by various factors including hepatic inflammation, extrahepatic cholestasis, heart failure, and underlying liver diseases. The aim of this study is to clarify the correlation between liver stiffness using SWE and hepatic necroinflammation serologically and pathologically. Methods A total of 843 patients with chronic liver disease who received liver biopsy were analyzed. Liver stiffness measurement using transient elastography (TE) and virtual touch quantification (VTQ) were carried out on the same day as the liver biopsy. The correlation between SWE and hepatic inflammation was analyzed serologically and pathologically. Results The liver stiffness values increased significantly with the progression of liver fibrosis and inflammation (overall p < 0.001). In patients with F0-1, F2, and F3, TE and VTQ values of A2 or A3 were significantly higher than those of A0 or A1 (p value, all <0.05), but not in patients with F4. The median alanine aminotransferase (ALT) values increased significantly with the progression of liver inflammation (p < 0.001). Moreover, TE and VTQ in patients with ALT >= 70 IU/L were significantly higher than those in patients with ALT <70 IU/L (p < 0.01), but not in patients with F4. Conclusion Shear wave elastography can be affected by hepatic necroinflammation in F0-F3 fibrosis, but not in F4.
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