Effect of coronary flow on intracoronary alteplase: a prespecified analysis from a randomised trial

Objectives Persistently impaired culprit artery flow (

Automated summary

This study evaluated the effects of intracoronary alteplase on persistently impaired culprit artery flow during primary percutaneous coronary intervention. The results showed that in patients with TIMI flow <= 2 pre-drug, alteplase was associated with increased risk of microvascular obstruction and myocardial hemorrhage.