High expression of bone morphogenetic protein 1 (BMP1) is associated with a poor survival rate in human gastric cancer, a dataset approaches

Bone morphogenetic protein 1 (BMP1) is a secreted metalloprotease of the astacin M12A family of bone morphogenetic proteins (BMPs). BMP1 activates transforming growth factor-beta (TGF-beta) and BMP signaling pathways by proteolytic cleavage, which has dual roles in gastrointestinal tumor development and progression. TGF-beta promotes invasion and metastasis of gastric cancer (GC) by the help of BMP1, so upregulation of the BMP1 may increase cancer invasiveness in GC. In this study,the transcriptional expression, mutations, survival rate, TFs, miRNAs, gene ontology, and signaling pathways of BMP1 were analyzed by using different web servers. We found higher transcriptional and clinicopathological characteristics expression compared to normal tissues, worsening survival rate in GC. We detected 25 missenses, 15 truncating mutations, 23 TFs, and 8 miRNAs. Finally, we identified and analyzed the co-expressed genes and found that the leukemia inhibitory factor is the most positively correlated gene. The gene ontological features and signaling pathways involved in GC development were evaluated as well. We believe that this study will provide a basis for BMP1 to be a significant biomarker for human GC prognosis.

Automated summary

BMP1 activates TGF-β and BMP signaling pathways in gastric cancer, promoting cancer invasiveness. The study reveals higher transcriptional expression and clinicopathological characteristics of BMP1 in GC compared to normal tissues, alongside worsening survival rate. It also identifies mutations, TFs, miRNAs, gene ontology features, and signaling pathways involved in GC development.