相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence
Maria Grazia Vizioli et al.
GENES & DEVELOPMENT (2020)
Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity
Estela Gonzalez-Gualda et al.
AGING CELL (2020)
Galactose-modified duocarmycin prodrugs as senolytics
Ana Guerrero et al.
AGING CELL (2020)
Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer
Marcus Ruscetti et al.
CELL (2020)
Benefits of Metformin in Attenuating the Hallmarks of Aging
Ameya S. Kulkarni et al.
CELL METABOLISM (2020)
A proteomic atlas of senescence-associated secretomes for aging biomarker development
Nathan Basisty et al.
PLOS BIOLOGY (2020)
Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity
Yonghan He et al.
NATURE COMMUNICATIONS (2020)
Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan
Laurent Grosse et al.
CELL METABOLISM (2020)
Senolytic CAR T cells reverse senescence-associated pathologies
Corina Amor et al.
NATURE (2020)
Senescence as a therapeutically relevant response to CDK4/6 inhibitors
Verena Wagner et al.
ONCOGENE (2020)
L1 drives IFN in senescent cells and promotes age-associated inflammation
Marco De Cecco et al.
NATURE (2019)
NAD+ metabolism governs the proinflammatory senescence-associated secretome
Timothy Nacarelli et al.
NATURE CELL BIOLOGY (2019)
Senolytic therapies for healthy longevity
Jan M. van Deursen
SCIENCE (2019)
Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
Lodoe Lama et al.
NATURE COMMUNICATIONS (2019)
The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype
Priya Hari et al.
SCIENCE ADVANCES (2019)
SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells
Christopher D. Wiley et al.
CELL REPORTS (2019)
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
LaTonya J. Hickson et al.
EBIOMEDICINE (2019)
Cellular Senescence: Defining a Path Forward
Vassilis Gorgoulis et al.
CELL (2019)
Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction
Stella Victorelli et al.
EMBO JOURNAL (2019)
Inducing and exploiting vulnerabilities for the treatment of liver cancer
Cun Wang et al.
NATURE (2019)
Identification and characterization of Cardiac Glycosides as senolytic compounds
Francisco Triana-Martinez et al.
NATURE COMMUNICATIONS (2019)
Pharmacological Inhibitors of the NLRP3 Inflammasome
Ayesha Zahid et al.
FRONTIERS IN IMMUNOLOGY (2019)
Cardiac glycosides are broad-spectrum senolytics
Ana Guerrero et al.
NATURE METABOLISM (2019)
Senescence and aging: Causes, consequences, and therapeutic avenues
Domhnall McHugh et al.
JOURNAL OF CELL BIOLOGY (2018)
PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells
Athena Georgilis et al.
CANCER CELL (2018)
A versatile drug delivery system targeting senescent cells
Daniel Munoz-Espin et al.
EMBO MOLECULAR MEDICINE (2018)
The invasin D protein from Yersinia pseudotuberculosis selectively binds the Fab region of host antibodies and affects colonization of the intestine
Pooja Sadana et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Strategies targeting cellular senescence
Yossi Ovadya et al.
JOURNAL OF CLINICAL INVESTIGATION (2018)
Senolytics improve physical function and increase lifespan in old age
Ming Xu et al.
NATURE MEDICINE (2018)
Targeting STING with covalent small-molecule inhibitors
Simone M. Haag et al.
NATURE (2018)
TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence
Thomas G. Bird et al.
SCIENCE TRANSLATIONAL MEDICINE (2018)
The Senescence-Stemness Alliance - A Cancer-Hijacked Regeneration Principle
Maja Milanovic et al.
TRENDS IN CELL BIOLOGY (2018)
NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination
Marcus Ruscetti et al.
SCIENCE (2018)
Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse
Marco Demaria et al.
CANCER DISCOVERY (2017)
The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
Birgit Ritschka et al.
GENES & DEVELOPMENT (2017)
Cytoplasmic chromatin triggers inflammation in senescence and cancer
Zhixun Dou et al.
NATURE (2017)
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
Selene Gluck et al.
NATURE CELL BIOLOGY (2017)
Targeting cellular senescence prevents age-related bone loss in mice
Joshua N. Farr et al.
NATURE MEDICINE (2017)
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
Ok Hee Jeon et al.
NATURE MEDICINE (2017)
cGAS is essential for cellular senescence
Hui Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2
Masaki Takasugi et al.
NATURE COMMUNICATIONS (2017)
Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
Jose Mario Gonzalez-Meljem et al.
NATURE COMMUNICATIONS (2017)
Cellular senescence mediates fibrotic pulmonary disease
Marissa J. Schafer et al.
NATURE COMMUNICATIONS (2017)
Identification of HSP90 inhibitors as a novel class of senolytics
Heike Fuhrmann-Stroissnigg et al.
NATURE COMMUNICATIONS (2017)
Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression
Kevin Contrepois et al.
NATURE COMMUNICATIONS (2017)
Unmasking Transcriptional Heterogeneity in Senescent Cells
Alejandra Hernandez-Segura et al.
CURRENT BIOLOGY (2017)
Quantitative identification of senescent cells in aging and disease
Anat Biran et al.
AGING CELL (2017)
Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression
Tobias Eggert et al.
CANCER CELL (2016)
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype
Christopher D. Wiley et al.
CELL METABOLISM (2016)
Mitochondria are required for pro-ageing features of the senescent phenotype
Clara Correia-Melo et al.
EMBO JOURNAL (2016)
MLL1 is essential for the senescence-associated secretory phenotype
Brian C. Capell et al.
GENES & DEVELOPMENT (2016)
HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci
Katherine M. Aird et al.
JOURNAL OF CELL BIOLOGY (2016)
Autophagy maintains stemness by preventing senescence
Laura Garcia-Prat et al.
NATURE (2016)
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Darren J. Baker et al.
NATURE (2016)
NOTCH1 mediates a switch between two distinct secretomes during senescence
Matthew Hoare et al.
NATURE CELL BIOLOGY (2016)
Senescent intimal foam cells are deleterious at all stages of atherosclerosis
Bennett G. Childs et al.
SCIENCE (2016)
Tissue damage and senescence provide critical signals for cellular reprogramming in vivo
Lluc Mosteiro et al.
SCIENCE (2016)
BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance
Nilgun Tasdemir et al.
CANCER DISCOVERY (2016)
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Yi Zhu et al.
AGING CELL (2015)
MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype
Hongshan Chen et al.
MOLECULAR CELL (2015)
mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
Nicolas Herranz et al.
NATURE CELL BIOLOGY (2015)
MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
Remi-Martin Laberge et al.
NATURE CELL BIOLOGY (2015)
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
Ming Xu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
Chanhee Kang et al.
SCIENCE (2015)
Targeting senescent cells enhances adipogenesis and metabolic function in old age
Ming Xu et al.
ELIFE (2015)
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
Marco Demaria et al.
DEVELOPMENTAL CELL (2014)
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Claudio Franceschi et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)
Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer
Diletta Di Mitri et al.
NATURE (2014)
Cellular senescence: from physiology to pathology
Daniel Munoz-Espin et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
mTOR inhibition improves immune function in the elderly
Joan B. Mannick et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
Enhancing Chemotherapy Efficacy in Pten-Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity
Alberto Toso et al.
CELL REPORTS (2014)
Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-B activation
Olga Moiseeva et al.
AGING CELL (2013)
Non-Cell-Autonomous Tumor Suppression by p53
Amaia Lujambio et al.
CELL (2013)
Programmed Cell Senescence during Mammalian Embryonic Development
Daniel Munoz-Espin et al.
CELL (2013)
Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
Mekayla Storer et al.
CELL (2013)
Cell fusion induced by ERVWE1 or measles virus causes cellular senescence
Anna Chuprin et al.
GENES & DEVELOPMENT (2013)
p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes
Albert R. Davalos et al.
JOURNAL OF CELL BIOLOGY (2013)
Lysosome-mediated processing of chromatin in senescence
Andre Ivanov et al.
JOURNAL OF CELL BIOLOGY (2013)
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
Shin Yoshimoto et al.
NATURE (2013)
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
Jan R. Doerr et al.
NATURE (2013)
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
Juan Carlos Acosta et al.
NATURE CELL BIOLOGY (2013)
A senescent cell bystander effect: senescence-induced senescence
Glyn Nelson et al.
AGING CELL (2012)
Glucocorticoids suppress selected components of the senescence-associated secretory phenotype
Remi-Martin Laberge et al.
AGING CELL (2012)
Chromatin Remodeling Underlies the Senescence-Associated Secretory Phenotype of Tumor Stromal Fibroblasts That Supports Cancer Progression
Ermira Pazolli et al.
CANCER RESEARCH (2012)
DNA Damage Signaling Triggers Degradation of Histone Methyltransferases through APC/CCdh1 in Senescent Cells
Akiko Takahashi et al.
MOLECULAR CELL (2012)
p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
Adam Freund et al.
EMBO JOURNAL (2011)
Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
Richard A. Miller et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2011)
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
Tae-Won Kang et al.
NATURE (2011)
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Darren J. Baker et al.
NATURE (2011)
Klotho suppresses RIG-I-mediated senescence-associated inflammation
Feng Liu et al.
NATURE CELL BIOLOGY (2011)
Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes
Masako Narita et al.
SCIENCE (2011)
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
Jean -Philippe Coppe et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)
Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity
Wyndham H. Wilson et al.
LANCET ONCOLOGY (2010)
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Francis Rodier et al.
NATURE CELL BIOLOGY (2009)
Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
Thomas Kuilman et al.
CELL (2008)
Chemokine signaling via the CXCR2 receptor reinforces senescence
Juan C. Acosta et al.
CELL (2008)
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Jean-Philippe Coppe et al.
PLOS BIOLOGY (2008)
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Wen Xue et al.
NATURE (2007)
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
Anna V. Molofsky et al.
NATURE (2006)
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
A Krtolica et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
分享论文
