期刊
DIABETES
卷 65, 期 6, 页码 1731-1740出版社
AMER DIABETES ASSOC
DOI: 10.2337/db15-1533
关键词
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资金
- China National Clinical Research Center for Metabolic Diseases [2013BAI09B13]
- National Basic Research Program of China (973 Program) [2015CB553600]
- National High-Tech Research and Development Program of China (863 Program) [2012AA020101]
- National Natural Science Foundation of China [81471059, 81471062, 81321001, 81390350, 81222008, 81270877]
- Joint Research Program for Important Diseases of the Shanghai Municipal Commission of Health and Family Planning [2013ZYJB1002]
- Shanghai Pujiang Project [14PJD024]
- Shu Guang Project of Shanghai Municipal Education Commission
- Shanghai Education Development Foundation [12SG21]
- Shanghai Municipal Education Commission [20152508]
We aimed to explore the causal association between type 2 diabetes (T2D) and increased arterial stiffness. We performed a Mendelian randomization (MR) analysis in 11,385 participants from a well-defined community study in Shanghai during 2011-2013. We genotyped 34 T2D-associated common variants identified in East Asians and created a genetic risk score (GRS). We assessed arterial stiffness noninvasively with the measurement of brachial-ankle pulse wave velocity (baPWV). We used the instrumental variable (IV) estimator to qualify the causal relationship between T2D and increased arterial stiffness. We found each 1-SD increase in T2D_GRS was associated with 6% higher risk in increased arterial stiffness (95% CI 1.01, 1.12), after adjustment of other metabolic confounders. Using T2D_GRS as the IV, we demonstrated a causal relationship between T2D and arterial stiffening (odds ratio 1.24, 95% CI 1.06, 1.47; P = 0.008). When categorizing the genetic loci according to their effect on insulin secretion or resistance, we found genetically determined decrease in insulin secretion was associated with increase in baPWV (beta(IV) = 122.3 cm/s, 95% CI 41.9, 204.6; P = 0.0005). In conclusion, our results provide evidence supporting a causal association between T2D and increased arterial stiffness in a Chinese population.
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