Chronic Liver Diseases and the Microbiome-Translating Our Knowledge of Gut Microbiota to Management of Chronic Liver Disease

Chronic liver disease is reaching epidemic proportions with the increasing prevalence of obesity, nonalcoholic liver disease, and alcohol overuse worldwide. Most patients are not candidates for liver transplantation even if they have end-stage liver disease. There is growing evidence of a gut microbial basis for many liver diseases, therefore, better diagnostic, prognostic, and therapeutic approaches based on knowledge of gut microbiota are needed. We review the questions that need to be answered to successfully translate our knowledge of the intestinal microbiome and the changes associated with liver disease into practice.

Automated summary

Chronic liver disease is becoming epidemic due to factors such as obesity, nonalcoholic liver disease, and alcohol overuse. Understanding the relationship between gut microbiota and liver diseases is crucial for developing improved diagnostic and therapeutic approaches. Knowledge of intestinal microbiome and its impact on liver disease could provide valuable insights for practical application in healthcare.