期刊
FRONTIERS IN NEUROENDOCRINOLOGY
卷 60, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2020.100873
关键词
Estradiol; Progesterone; Decision making; Reward processing; Menstrual cycle; Dopamine; Serotonin; Substance use disorder; Depression
资金
- German Research Foundation, DFG [DE2319/2-4, DE2319/6-1, DE2319/9-1]
- Research Council of Norway [250358]
Research has shown behavioral differences in women and men when making value-based decisions, possibly influenced by functional lateralization of the brain, neurotransmitter systems, and sex hormones. Decision-making in women may be more susceptible to the effects of ovarian hormones, but there is still limited understanding in this area.
Women and men exhibit differences in behavior when making value-based decisions. Various hypotheses have been proposed to explain these findings, stressing differences in functional lateralization of the brain, functional activation, neurotransmitter involvement and more recently, sex hormones. While a significant interaction of neurotransmitter systems and sex hormones has been shown for both sexes, decision-making in women might be particularly affected by variations of ovarian hormones. In this review we have gathered information from animal and human studies on how ovarian hormones affect decision-making processes in females by interacting with neurotransmitter systems at functionally relevant brain locations and thus modify the computation of decision aspects. We also review previous findings on impaired decision-making in animals and clinical populations with substance use disorder and depression, emphasizing how little we know about the role of ovarian hormones in aberrant decision-making.
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