期刊
FREE RADICAL RESEARCH
卷 55, 期 5, 页码 499-509出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10715762.2020.1860213
关键词
Tetrahydrobiopterin autoxidation; photooxidation; molecular oxygen; density functional theory; Gibbs free energy
资金
- Russian Science Foundation [20-73-10029]
- Russian Science Foundation [20-73-10029] Funding Source: Russian Science Foundation
This study evaluated the feasibility of reactions involved in the autoxidation and photooxidation of the coenzyme H(4)Bip using theoretical methods of quantum chemistry. The interactions between H(4)Bip, its derivatives, molecular oxygen, and reactive oxygen species (ROS) were analyzed, along with the reactivity of specific atoms in the molecule. The findings contribute to a better understanding of the oxidization processes of H(4)Bip and its potential implications in biological systems.
Pterins are naturally occurring pigments and enzyme cofactors widespread in living organisms. Tetrahydrobiopterin (H(4)Bip) is a coenzyme of aromatic amino acid hydroxylases, NO-synthases, and alkylglycerol monooxygenases. This coenzyme is prone to oxidation in the presence of molecular oxygen, a so-called autoxidation. The reactions participating in H(4)Bip autoxidation are well known. However, our study is an attempt to evaluate theoretically the feasibility of reactions participating in autoxidation. To do so, we have calculated the Gibbs free energy of elementary reactions between H(4)Bip, its derivatives, molecular oxygen, and reactive oxygen species (ROS). In the last few years, we have established the photosensitized oxidation of H(4)Bip experimentally. Thus, we have also evaluated the feasibility of H(4)Bip photooxidation reactions, which may occur according to both type-I and type-II photosensitized oxidation. We calculated Fukui indices for H(4)Bip and found particular atoms in the molecule that interact with nucleophiles (for example, singlet oxygen O-1(2)) and radicals (in particular, molecular oxygen O-3(2)). Therefore, we evaluated the probability of H(4)Bip autoxidation reactions, photooxidation reactions, and the reactivity of particular atoms in H(4)Bip molecule using the theoretical methods of quantum chemistry.
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