期刊
FOOD CHEMISTRY
卷 348, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2021.129111
关键词
Immunomodulation; Peptide; beta-casein; Monocytes; Nuclear factor (NF)-kappa B; Mitogen-activated protein kinase (MAPK)
资金
- National Natural Science Foundation of China [81701491, 81601333, 81770837, 81702569]
- Natural Science Foundation of Jiangsu Province, China [BK20170152, BK20181089, BK20170151]
- Jiangsu Provincial Medical Youth Talent [QNRC2016108]
In this study, a novel peptide named BCCY-1 corresponding to human beta-casein sequence was identified in human milk, showing immunomodulatory activity by enhancing monocyte migration. BCCY-1 exerts its effects by activating NF-κB and MAPK signaling pathways.
In this study, we report a novel peptide corresponding to the sequence of human beta-casein (named BCCY-1), which was identified in our previous peptidome analysis of human milk and has great immunomodulatory activity. The results revealed that peptide BCCY-1, but not the scrambled version, enhanced monocyte migration without obvious toxicities. This selective effect was mediated via increased production of chemokines by peptide stimulated monocytes. Moreover, BCCY-1 exerted its modulatory effects by activating nuclear factor (NF)-kappa B and mitogen-activated protein kinase (MAPK) signaling. The abundances of peptide BCCY-1 and the peptides partially encompassing its fragment were found to be lower in preterm milk than in term milk. Our study may lead to new insights into the immunoregulatory effects of casein-derived peptides and facilitate the discovery of novel peptide-based food and pharmaceutical products.
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