期刊
EXPERIMENTAL DERMATOLOGY
卷 30, 期 5, 页码 698-704出版社
WILEY
DOI: 10.1111/exd.14281
关键词
aggressiveness; biomarker; Cancer-associated fibroblasts; recessive dystrophic epidermolysis; tumorigenesis
类别
资金
- Congressionally Directed Medical Research Program [NIH RO1 AR47981, RC4AR060535, RO1 AR33625]
- [W81XWH-1810558]
Periostin expression in cSCC is primarily found in the peritumoral microenvironment and is correlated with aggressiveness, suggesting it could serve as a molecular marker for subtyping and diagnosing cSCCs.
Periostin, an extracellular matrix macromolecule implicated in tumorigenesis, serves as a prognostic marker for many cancer types. However, there are no data on periostin expression in cutaneous squamous cell carcinoma (cSCC). This study examined periostin expression in patients with cSCC and explored its clincopathological relationship and prognosis. Using immunohistochemistry and ImageJ analysis, we compared periostin expression in 95 cSCCs across a spectrum of cSCC aggressiveness: cSCC in situ (SCCIS) (n = 25), low-risk cSCC (LR-cSCC) (n = 26), high-risk cSCC (HR-cSCC) (n = 38), and cSCC in recessive dystrophic epidermolysis bullosa patients (RDEB cSCC) (n = 6). Immunohistochemistry demonstrated periostin expression within the intra-tumoral stroma but not within tumor cells. Periostin levels significantly (P < 0.001) increased from SCCIS, LR-cSCC, HR-cSCC to RDEB SCC. The stroma of most of the cSCCs we evaluated contained cancer-associated fibroblasts with a myofibroblastic (alpha -SMA-positive) phenotype. Co-localization of periostin with alpha-SMA, evidence of fibroblast periostin expression, and absence of keratinocyte or tumor cell periostin expression suggest that, in cSCC, periostin is a product of the peritumoral microenvironment and not the tumor cells themselves. Our data indicate that fibroblast periostin expression is highly correlated with the aggressiveness of cSCC, and may thereby provide a molecular marker that will be useful for subtyping and diagnosing cSCCs according to their biological nature.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据