期刊
EXPERIMENTAL DERMATOLOGY
卷 30, 期 4, 页码 529-545出版社
WILEY
DOI: 10.1111/exd.14247
关键词
cutaneous squamous cell carcinomas; epigenetic regulators; lineage plasticity; signalling transduction; skin epithelial stem cells; transcription factors
类别
资金
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [1K01AR072132]
- Cancer Prevention and Research Institute of Texas [FP00006955]
Epithelial stem cells play crucial roles in maintaining skin homeostasis, wound repair, and cancer, with their function tightly controlled by various transcriptional and signaling mechanisms. After injury, stem cells exhibit lineage plasticity and adjust their differentiation fate according to damage signals.
The epidermis and skin appendages are maintained by their resident epithelial stem cells, which undergo long-term self-renewal and multilineage differentiation. Upon injury, stem cells are activated to mediate re-epithelialization and restore tissue function. During this process, they often mount lineage plasticity and expand their fates in response to damage signals. Stem cell function is tightly controlled by transcription machineries and signalling transductions, many of which derail in degenerative, inflammatory and malignant dermatologic diseases. Here, by describing both well-characterized and newly emerged pathways, we discuss the transcriptional and signalling mechanisms governing skin epithelial homeostasis, wound repair and squamous cancer. Throughout, we highlight common themes underscoring epithelial stem cell plasticity and tissue-level crosstalk in the context of skin physiology and pathology.
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