Chitosan/mesoporous silica hybrid aerogel with bactericidal properties as hemostatic material

A N-halamine precursor monomer, (3-acrylamidopropyl) trimethylammonium chloride (APTMAC) was attached onto mesoporous silica. The hydrogel of chitosan and mesopomus silica-supported N-halamine precursors (MSSNPs) was prepared with gamma-chloropropyl-triethoxysilane (CPTES) as the cross-linking agent. A porous three-dimensional microstructure of the siloxane aerogels with low density and high porosity was obtained through lyophilization. After chlorination, the aerogels showed potent bactericidal activities against 100% of S. aureus (7.44 log) and E. coli O157:H7 (7.02 log) within 30 min. Compared with traditional hemostatic materials (pledget and bandage), siloxane aemgels displayed good liquid retention rate and hemostatic properties. Erythrocytes and platelets showed good adhesion properties on the surface of the aemgels. The N-halamine-based aerogels showed good bactericidal and hemostatic properties, which have potential application for wound dressings.

Automated summary

In this study, a novel N-halamine-based aerogel was developed by attaching N-halamine precursor monomer onto mesoporous silica and cross-linking with gamma-chloropropyl-triethoxysilane. The aerogel demonstrated potent bactericidal and hemostatic properties, showing potential for application in wound dressings.