Cobalt(II)-Catalyzed C-H/N-H Functionalization and Annulation of N-(quinolin-8-yl)benzamide with Cyclopropanols

A new method for Co-catalyzed C-H/N-H functionalization and [4+1] annulation of N-(quinolin-8-yl)benzamide with cyclopropanols was developed. This protocol tolerates a variety of functional groups, thereby providing an efficient method for the fabrication of isoindolin-1-ones. Moreover, the utility of this strategy was showcased by the late-stage modification of lithocholic acid derivatives and ibuprofen derivatives.

Automated summary

A new method for the synthesis of isoindolin-1-ones was developed through Co-catalyzed C-H/N-H functionalization and [4+1] annulation, showcasing its utility in late-stage modification of lithocholic acid derivatives and ibuprofen derivatives.