期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2021, 期 6, 页码 944-950出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202001479
关键词
Annulation; CDC reaction; DDQ; 2; 3-Dihydroquinazolin-4(1H)-one; Oxidation
资金
- Natural Science Foundation of China [21602197]
- Natural Science Foundation of Zhejiang Province [LY18B020018]
An efficient tandem oxidative annulation for the synthesis of 2,2-disubstituted 2,3-dihydroquinazolin-4(1H)-ones via DDQ-mediated dual cross-dehydrogenative-coupling (CDC) reactions is described, resulting in moderate to excellent yields of the corresponding products.
An efficient tandem oxidative annulation for the synthesis of 2,2-disubstituted 2,3-dihydroquinazolin-4(1H)-ones via DDQ-mediated dual cross-dehydrogenative-coupling (CDC) reactions is described. This transformation proceeds from easily available o-aminobenzamides and 1,3-diarylpropenes under mild conditions, and the corresponding products are obtained in moderate to excellent yields.
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