Iodine-Mediated Coupling of Cyclic Amines with Sulfonyl Hydrazides: an Efficient Synthesis of Vinyl Sulfone Derivatives

An efficient iodine-mediated coupling of cyclic amines with sulfonyl hydrazides is reported. This transformation opens a new route to the synthesis of vinyl sulfones derivatives, which is a common structural motif in natural products and pharmaceuticals. Tentative mechanistic studies suggest that this reaction is likely to involve a radical process.

Automated summary

An efficient iodine-mediated coupling reaction of cyclic amines with sulfonyl hydrazides was reported, providing a new route to the synthesis of vinyl sulfone derivatives. Tentative mechanistic studies suggest that this reaction likely proceeds through a radical process.