期刊
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
卷 48, 期 6, 页码 1998-2008出版社
SPRINGER
DOI: 10.1007/s00259-020-05092-3
关键词
Ovarian cancer; F-18-FDG; PET; PERCIST; MATV
资金
- Boehringer Ingelheim
The ancillary study evaluated F-18-FDG PET parameter changes after one cycle of treatment in patients receiving neoadjuvant anti-angiogenic nintedanib combined with chemotherapy. The study showed that EORTC or PERCIST criteria are useful tools in predicting survival and second-look surgery outcome. However, MATV and TLG were not found to be useful in predicting survival in ovarian cancer patients.
BackgroundThis ancillary study aimed to evaluate F-18-FDG PET parameter changes after one cycle of treatment compared to baseline in patients receiving first-line neoadjuvant anti-angiogenic nintedanib combined to paclitaxel-carboplatin chemotherapy or chemotherapy plus placebo and to evaluate the ability of F-18-FDG PET parameters to predict progression-free survival (PFS), overall survival (OS), and success of second-look surgery.Materials and methodsCentral review was performed by two readers blinded to the received treatment and to the patients' outcome, in consensus, by computing percentage change in PET metrics within a volume of interest encompassing the entire tumor burden. EORTC and PERCIST criteria were applied to classify patients as responders (partial metabolic response and complete metabolic response) or non-responders (stable metabolic disease and progressive metabolic disease). Also analyzed was the percentage change in metabolic active tumor volume (MATV) and total lesion glycolysis (TLG).ResultsTwenty-four patients were included in this ancillary study: 10 received chemotherapy + placebo and 14 chemotherapy + nintedanib. PERCIST and EORTC criteria showed similar discriminative power in predicting PSF and OS. Variation in MATV/TLG did not predict PFS or OS, and no optimal threshold could be found for MATV/TLG for predicting survival. Complete cytoreductive surgery (no residual disease versus residual disease <0.25 cm/0.25-2.5 cm/>2.5 cm) was more frequent in responders versus non-responders (P=0.002 for PERCIST and P=0.02 for EORTC criteria). No correlation was observed between the variation of PET data and the variation of CA-125 blood level between baseline sample and that performed contemporary to the interim PET, but a statistically significant correlation was observed between Delta SULpeak and Delta CA-125 between baseline sample and that performed after the second cycle.Conclusion(18)F-FDG PET using EORTC or PERCIST criteria appeared to be a useful tool in ovarian cancer trials to analyze early tumor response, and predict second-look surgery outcome and survival. An advantage of PERCIST is the correlation of Delta SULpeak and Delta CA-125, PET response preceding tumor markers response by 1 month. Neither MATV nor TLG was useful in predicting survival.Trial registrationNCT01583322 ARCAGY/ GINECO GROUP GINECO-OV119, 24 April 2012
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