期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 214, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2021.113218
关键词
Pyrimidine-fused bicyclic heterocycles; Cancer therapy; Chemical synthesis
资金
- National Natural Science Foundation of China [81703326, 81973177]
- Program for Science & Technology Innovation Talents in Universities of Henan Province [21HASTIT045]
- Henan Scientific Innovation Talent Team, Department of Education [19IRTSTHN001]
Considerable progress has been achieved in the development of anticancer agents in recent decades, with pyrimidine-fused bicyclic heterocycles showing potential for clinical treatment. New anticancer agents have been produced from natural and synthetic sources, with a focus on improving therapeutic efficacy for various cancers.
Considerable progress has been made in the development of anticancer agents over the past few decades, and a lot of new anticancer agents from natural and synthetic sources have been produced. Among heterocyclic compounds, pyrimidine-fused bicyclic heterocycles possess a variety of biological activities such as anticancer, antiviral, etc. To date, 147 pyrimidine-fused bicyclic heterocycles have been approved for clinical assessment or are currently being used in clinic, 57 of which have been approved by FDA for clinical treatment of various diseases, and 22 of them are being used in the clinic for the treatment of different cancers. As the potentially privileged scaffolds, pyrimidine-fused bicyclic heterocycles may be used to discover new drugs with similar biological targets and improved therapeutic efficacy. This review aims to provide an overview of the anticancer applications and synthetic routes of 22 approved pyrimidine-fused bicyclic heterocyclic drugs in clinic. (C) 2021 Elsevier Masson SAS. All rights reserved.
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