期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 209, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2020.112886
关键词
Oxadiazole; Anti-Tuberculosis; SAR; Drug discovery
资金
- School of Chemistry and Chemical Engineering, Yulin University
This review summarizes the current innovations of oxadiazole-based derivatives with potential antituberculosis activity, discussing their role as bioisosteric substitutions and interactions with anti-TB targets.
With the increasing number of cases of inactive and drug-resistance tuberculosis, there is an urgent need to develop new potent molecules set for fighting this brutal disease. Medicinal chemistry concerns the discovery, the development, the identification, and the interpretation of the mode of action of biologically active compounds at the molecular level. Molecules bearing oxadiazoles are one such class that could be considered to satisfy this need. Oxadiazole regioisomers have been investigated in drug discovery programs for their capacity to go about as powerful linkers and as pharmacophoric highlights. Oxadiazoles can go about as bioisosteric substitutions for the hydrazide moiety which can be found in first-line anti-TB drugs, and some have been likewise answered to cooperate with more current anti-TB targets. This present review summarizes the current innovations of oxadiazole-based derivatives with potential antituberculosis activity and bacteria discussing various aspects of structure-activity relationship (SAR). (c) 2020 Elsevier Masson SAS. All rights reserved.
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