Recent advances in drug discovery against Mycobacterium tuberculosis: Metal-based complexes

Metal-based drugs are privileged motifs that act as primary pharmacophores in bioactive compounds for various diseases, including tuberculosis (TB). This potentially life-threatening and extremely contagious infectious disease is caused by Mycobacterium tuberculosis (Mtb). In 2018, TB infected about 10 million people and caused 1.2 million deaths worldwide. A large number of ligands are promising scaffolds in drug design, including heterocyclic, phosphines, schiff bases, thio and semicarbazones, aliphatic amines, cyclopalladated, cyanometallates and miscellaneous. Moreover, several metal-based complexes have been studied for the treatment of numerous illnesses, including infectious diseases. To contribute to drug design, we identified the metal-based organometallic complexes against Mtb. Thus, in this review article, we analysed the recent contributions of metal-based scaffolds for design of new anti-Mtb drugs in the last decade (2011-2020). Besides, metal-based approaches will be presented in order to find out new antitubercular agents. (C) 2021 Elsevier Masson SAS. All rights reserved.

Automated summary

Metal-based drugs serve as key pharmacophores in the development of new anti-TB drugs, with promising ligands like heterocyclic compounds, phosphines, schiff bases, thio and semicarbazones, aliphatic amines, cyclopalladated, cyanometallates. Metal-based complexes show potential for treating various diseases, including infectious diseases.