相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Red-Emitting Dibenzodiazepinone Derivatives as Fluorescent Dualsteric Probes for the Muscarinic Acetylcholine M2 Receptor
Xueke She et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
A Dynamic, Split-Luciferase-Based Mini-G Protein Sensor to Functionally Characterize Ligands at All Four Histamine Receptor Subtypes
Carina Horing et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Differently fluorescence-labelled dibenzodiazepinone-type muscarinic acetylcholine receptor ligands with high M2R affinity
Corinna G. Gruber et al.
RSC MEDICINAL CHEMISTRY (2020)
Conjugation of Short Peptides to Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Determines M2R Selectivity
Andrea Pegoli et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Cholinergic muscarinic M1 and M4 receptors as therapeutic targets for cognitive, behavioural, and psychological symptoms in psychiatric and neurological disorders
Daniel Erskine et al.
DRUG DISCOVERY TODAY (2019)
Structural insights into the subtype-selective antagonist binding to the M2 muscarinic receptor
Ryoji Suno et al.
NATURE CHEMICAL BIOLOGY (2018)
Radiolabeled Dibenzodiazepinone-Type Antagonists Give Evidence of Dualsteric Binding at the M2 Muscarinic Acetylcholine Receptor
Andrea Pegoli et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Heterodimerization of Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Leads to Increased M2R Affinity and Selectivity
Xueke She et al.
ACS OMEGA (2017)
Carbachol dimers as homobivalent modulators of muscarinic receptors
Rosanna Matucci et al.
BIOCHEMICAL PHARMACOLOGY (2016)
Crystal structures of the M1 and M4 muscarinic acetylcholine receptors
David M. Thal et al.
NATURE (2016)
M2 Subtype preferring dibenzodiazepinone-type muscarinic receptor ligands: Effect of chemical homo-dimerization on orthosteric (and allosteric?) binding
Max Keller et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2015)
Rational Design of Partial Agonists for the Muscarinic M1 Acetylcholine Receptor
Xinyu Chen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Dualsteric Muscarinic Antagonists-Orthosteric Binding Pose Controls Allosteric Subtype Selectivity
Jens Schmitz et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Muscarinic acetylcholine receptors: novel opportunities for drug development
Andrew C. Kruse et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Molecular Alliance - From Orthosteric and Allosteric Ligands to Dualsteric/Bitopic Agonists at G Protein Coupled Receptors
Klaus Mohr et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
Activation and allosteric modulation of a muscarinic acetylcholine receptor
Andrew C. Kruse et al.
NATURE (2013)
Bridging the gap: bitopic ligands of G-protein-coupled receptors
J. Robert Lane et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2013)
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
Kazuko Haga et al.
NATURE (2012)
The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling
Andreas Bock et al.
NATURE COMMUNICATIONS (2012)
Rational design of dualsteric GPCR ligands: quests and promise
Klaus Mohr et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
Structural Determinants of Allosteric Agonism and Modulation at the M4 Muscarinic Acetylcholine Receptor IDENTIFICATION OF LIGAND-SPECIFIC AND GLOBAL ACTIVATION MECHANISMS
Vindhya Nawaratne et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Orthosteric and Allosteric Modes of Interaction of Novel Selective Agonists of the M1 Muscarinic Acetylcholine Receptor
Vimesh A. Avlani et al.
MOLECULAR PHARMACOLOGY (2010)
Alzheimer's disease: strategies for disease modification
Martin Citron
NATURE REVIEWS DRUG DISCOVERY (2010)
Allosteric Ligands for G Protein-Coupled Receptors: A Novel Strategy with Attractive Therapeutic Opportunities
Marco De Amici et al.
MEDICINAL RESEARCH REVIEWS (2010)
Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity
Johannes Antony et al.
FASEB JOURNAL (2009)
An optical dynamic mass redistribution assay reveals biased signaling of dualsteric GPCR activators
Anna Kebig et al.
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2009)
Novel Selective Allosteric Activator of the M1 Muscarinic Acetylcholine Receptor Regulates Amyloid Processing and Produces Antipsychotic-Like Activity in Rats
Carrie K. Jones et al.
JOURNAL OF NEUROSCIENCE (2008)
A novel multivalent ligand that bridges the allosteric and orthosteric binding sites of the M2 muscarinic receptor
Tod Steinfeld et al.
MOLECULAR PHARMACOLOGY (2007)
Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
Juergen Wess et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Design, synthesis, and action of oxotremorine-related hybrid-type allosteric modulators of muscarinic acetylcholine receptors
T Disingrini et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Allosterism at muscarinic receptors: Ligands and mechanisms
NJM Birdsall et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2005)
Muscarinic receptor agonists and antagonists in the treatment of Alzheimer's Disease
JW Clader et al.
CURRENT PHARMACEUTICAL DESIGN (2005)
Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity
JW Clader et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2004)
Muscarinic M1 receptor agonists and M2 receptor antagonists as therapeutic targets in Alzheimer's disease
MJ Sheardown
EXPERT OPINION ON THERAPEUTIC PATENTS (2002)
Therapeutic, opportunities from muscarinic receptor research
RM Eglen et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2001)
Muscarinic receptor agonists and antagonists
KJ Broadley et al.
MOLECULES (2001)