期刊
DEVELOPMENTAL DYNAMICS
卷 245, 期 10, 页码 976-990出版社
WILEY
DOI: 10.1002/DVDY.24432
关键词
human embryonic stem cells; morphogen; gastrulation; dynamics; signaling
资金
- National Science Foundation [MCB-1553228]
- Cancer Prevention Research Institute of Texas [RR140073]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1553228] Funding Source: National Science Foundation
In vivo studies have identified the signaling pathways and transcription factors involved in patterning the vertebrate embryo, but much remains unknown about how these are organized in space and time to orchestrate embryogenesis. Recently, embryonic stem cells have been established as a platform for studying spatial pattern formation and differentiation dynamics in the early mammalian embryo. The ease of observing and manipulating stem cell systems promises to fill gaps in our understanding of developmental dynamics and identify aspects that are uniquely human. (C) 2016 Wiley Periodicals, Inc.
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